is surface and reverse disorganization of connective tissue characterized by intensified metachromatic reaction to glucosaminoglycanes and hydration of basal substance. Mucous edema

Systemic Diseases of Connective Tissue with Autoimmunization. Rheumatism. Rheumatoid Arthritis. Systemic Lupus Erythematosus. Scleroderma. Dermatomyositis. Bechterew’s (Strumpell’s) disease Systemic Diseases of Connective Tissue or Rheumatic diseases are a group of chronic diseases characterized by systemic lesion of connective tissue and blood vessels. In their aetiology a significant role is played by a clinically apparent or latent streptococcic infection and the pathogenetic mechanisms mainly consist in allergic reactions of delayed and immediate type. There develops progressive disorganization of connective tissue – a mucous edema, a fibrinoid edema and necrosis,  cellular reaction (granulomatosis) and sclerosis.